Furthermore, misaligning the cortisol rhythm has been shown to induce profound cardiovascular and renal disease sequel, which was subsequently reversed by light exposure therapy in hamsters [54].
Duration of people living with disabilities in each disease sequel is not possible without a cohort study to monitor disease progression.
The estimation of YLD essentially demands extensive data on proportion of disease sequel, hardly available in developing countries where limited epidemiological studies have been conducted.
First, disability weights (DW) were mostly derived from the GBD with a few exceptions where the Dutch weights were applied instead due to the fact that we classified disease sequel according to the Australia's study which then used the Dutch weights.
Therefore, we reasonably rely on information of nature of disease and sequel from developed countries.
The authors outline the situation of Brazil, where the classification system in force is still based on "addition of categories based on diseases and sequels" within a purely medical model.
Breast cancer is not a medical emergency but the procrastination of onset of diagnostic work-up and treatment is likely to result in further advanced disease and its probable sequels like more invasive surgery or higher cause specific mortality.
The high prevalence in pancreatic, and particularly, in colorectal cancers seems to be the consequence of a combination of blood loss and inflammatory response, while in lung cancer, both the disease itself and the sequels of toxic chemotherapy, which likely induces a strong inflammatory response, may account for ID.
Therefore, disease activity, as a sequel to the inflammatory events, directly or indirectly steers all of the characteristics and consequences of RA, which in turn have partial influence on each other as further detailed in this commentary.
These diseases have received special attention of public health officials due to the large number of infected people in tropical and subtropical countries and the possible sequels that those diseases can cause.
Another particular sequel of the disease is having an enterostomy constructed at surgery for peritonitis, which in these patients is usually still present at six months follow-up.
