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These days everybody is trying to justify their biology work in terms of disease relevance.
In the era of long-term inhaled antibiotics and increasing CF patient survival, new "emerging" pathogens are detected in CF airways, yet their pathophysiological disease relevance remains largely controversial and incompletely defined.
Whereas the prevalence (or at least the detection rate) of these microbial species increases in most CF centers, their pathophysiological disease relevance for the outcome of CF lung disease remains controversial and poorly defined.
To investigate the potential disease relevance of novel miRNAs, we compared different expression of novel miRNAs in the patient group with normal control.
We checked the disease relevance of these two microRNAs using the miR2Disease database [35], a manually curated database that aims at documenting known relationships between microRNA dysregulation and human disease.
Therefore, the quantitative PCR procedure confirmed the majority of the microarray analysis, for the genes investigated that had brain disease relevance discussed below, but some differences were observed for various technical reasons.
We first examined expansion sizes as one indicator of disease relevance.
However, both the molecular function and the disease relevance of the spliced lncRNA 116HG are unknown.
Another expansion of the efforts is horizontally toward biological functions and disease relevance [13 15].
Still, presuming a multigenic threshold model for MR, disease relevance cannot be completely ruled out.
Nevertheless, tools to accurately assign functional and disease relevance to sequence variants are substantially lacking.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com