Further, as the classification of diseases becomes refined, it becomes increasingly difficult to conduct statistical analyses with adequate power to address questions about the effects of an exposure on disease incidence.
It helps to reveal mechanisms of disease, to refine molecular diagnostics, and to discover, develop, and deliver drugs (e.g. Hrkach et al. [2012]).
Though their role in guiding lung cancer radiotherapy is not yet established, the panel of imaging biomarkers represents a distinct trend towards personalized molecular profiling of patient disease to refine both staging and target definition.
At many levels, a more detailed picture of the disease is being refined and advanced, but other aspects of the disease remain highly enigmatic.
There is a general understanding that physicians face an increased risk of contagion from disease, an understanding refined during schooling and training".
The findings of these studies will also improve our understanding of the underlying biology of the diseases and refine their clinical management.
Even so, disease classifications are constantly being refined, and separating diseases into subtypes can improve the clinical utility of the disease description.
The RCM assist of the diagnosis and differential diagnosis of skin diseases can be refined and a more specific opinion can be provided without or before a surgical biopsy.
Given this evidence of interaction between TNF and MTHFR in AUD and depression, and consistent with expected environmental influences on complex diseases, we further refined the hypothesis to include gene-by-environment interaction influencing the comorbidity.
The core set has served the scientific community well but it is likely that many of the measures for RA and for other diseases will be refined with the development of new patient-reported outcomes such as those produced by the National Institutes of Health's Patient Reported Outcomes Measurement Information System initiative (for example).
