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Freeman, T. B.; Cicchetti, F.; Hauser, R. A.; Deacon, T. W.; Li, X.-J.; Hersch, S. M.; Nauert, G. M.; Sanberg, P. R.; Kordower, J. H.; Saporta, S.; Isacson, O. : Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology.
The most recent, the Vienna Classification arose from a 1998 World Congress of Gastroenterology Working Party that attempted to prospectively design a simple and objective Crohn's disease phenotypic classification that encompassed components of age at onset, anatomic location and disease behavior.
Potential challenges include the small number of individuals affected, lack of understanding of the natural history of the disease, phenotypic heterogeneity, and lack of validated endpoints for use in clinical trials.
While target-based drug discovery, at some level, implies that you have at least a core kernel of understanding for what drives a disease, phenotypic screening is arguably associated with the more humble recognition that you really don't believe you understand most of what's going on, and the conceit is that perhaps you don't need to.
Recent computational approaches incorporate disease phenotypic similarities to improve the prediction power of disease gene discovery.
The heterogeneous network is composed of disease phenotypic similarities, disease-protein associations and protein-protein interactions.
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Thus, even for indications, a high drug-disease phenotypic similarity might alert for potential drug-induced aggravation of the disease condition.
Our comprehensive list of bimodal genes in the mouse will be useful in identifying disease-phenotypic alterations in gene regulation in diseases such as cancer, hypertension and diabetes.
Conte, M. P. et al. Adherent-invasive Escherichia coli (AIEC) in pediatric Crohn's disease patients: phenotypic and genetic pathogenic features.
However, as with most clinical records describing human disease, the phenotypic data available for autism contains varying levels of noise and incompleteness that complicate analysis.
Studies on autism spectrum disorder (ASD) have amassed substantial evidence for the role of genetics in the disease's phenotypic manifestation.
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