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In addition, it was evident that a shift in cytokine profile occurred during acute and relapsing disease phases.
Corticosteroid use during early disease phases is accepted for control of acute inflammation and constitutional symptoms, but is controversial for overall treatment [12].
Another challenge for new drug developments, where the C-HPP deliveries can play a role are disease phases and complex patho-physiology that needs to be understood for any given treatment.
While magnetic resonance imaging (MRI) has been proven useful in the early disease phases, the present routine MRI protocols are only of limited value for the prediction of long term prognosis of MS [3].
To that end, protein levels of GFAP were investigated by Western Blot (Fig. 2) over the course of the disease at an early chronic (day 35 p.i). and late chronic time point of MOG-EAE (day 60 p.i .. Quantification of protein levels revealed a significant, up to 2 fold increase of GFAP protein levels in the later disease phases (Fig. 2B).
However, little is known about these antibodies' specific role or profile according to disease phases.
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PLCH appearance on the first CT examination depends on the disease phase [17].
In humans, the pathogenic cycle of TB consists of three phases [7]: i) an active TB disease phase with actively replicating bacteria; ii) a latent phase wherein bacteria achieves a phenotypically distinct drug resistant state; and iii) a reactivation phase.
We also observed a small but highly significant reduction in apoptosis with MCP in the later disease phase.
Our results suggest a progression of distinct biochemical disturbances, which may be intermittent in the prodromal disease phase.
Therefore it appears that axotomy has opposing effects on motoneuron survival depending on what disease phase is used as the experimental end point.
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