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These data support a critical role for LT-β producing B cells in sustaining principal disease pathways in rheumatoid synovitis.
Bu, G. Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy.
The foundation paid for investigations into genetics, stem cells, gene therapy, accelerated drug testing and disease pathways.
While that's good, we must also address the animal-to-human disease pathways that put us at risk.
PhenomeExpress was used to build gene expression subnetworks in RA and OA and identify core disease pathways.
Miller, J. A., Horvath, S. & Geschwind, D. H. Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways.
These agents selectively modulate TNF-mediated disease pathways leading to reduced inflammatory activity.
More broadly, CRISPR screens like the one in this study have been used to investigate a range of disease pathways.
These discoveries provide insights into the molecular pathogenesis of ciliopathies and illustrate the power of linking proteomics technologies with human genetics to uncover critical disease pathways.
Moreover, the challenging question lying ahead of us is how genetic and environmental factors translate to molecular disease pathways.
Enhancing effector function, antibody drug conjugates (ADC) or targeting multiple disease pathways via multi-specific antibodies are being explored.
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CEO of Professional Science Editing for Scientists @ prosciediting.com