The sequence typing process was applied three times: on the invasive disease isolates (n = 378) joined with a data set of carriage isolates from the UK (n = 520), USA (n = 622) and Iceland (n = 622).
This prompted us to examine the prevalence and sequence diversity of these proteins in a panel of N. meningitidis disease isolates.
"I am skeptical about the completeness of the evolutionary story when it is based exclusively on the remnants of human disease isolates".
None of the disease isolates were resistant to vancomycin.
In contrast, 67.4% of the carriage isolates and 38.8% of the disease isolates correspond to Group 1b.
The CC199 phylogeny split into two main clades, one comprised predominantly of carriage isolates and another of disease isolates.
Two of those studies focused on C. perfringens animal disease isolates (type B to E) [25], [26].
ST88 is the most convincing case, accounting for 14% of the disease isolates and>1% of the carriage isolates.
Group 2 accounts for 30/49 (61.2%) of the disease isolates but only 46/141 (32.6%) of the carriage isolates.
As noted previously [10], the distribution of the MDA in the collection of disease isolates was not uniform by age of patient.
We examined a larger number of MenB cc269 with 241 carriage isolates and 421 disease isolates from seven regions of the UK.
