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Although many patients have widespread disease, isolated metastases can be found.
Starting point is to detect potential signs of pre-existing chronic cardiac dysfunction (Step 1): LV or LA significant dilatation, and LV marked hypertrophy are signs or chronic volume/pressure overload; RA significant dilatation, RV dilatation and hypertrophy have the same meaning for right-side chronic disease (isolated RV dilatation can vice versa be a sign of acute RV dysfunction).
The United Kingdom may soon have an answer to a question that has been harrowing the country since 1996: Are the 34 cases of a fatal brain disease that is thought to be the human form of "mad cow disease" isolated occurrences, or signs of an impending epidemic?
So it turns out that Lyme is not a regional disease isolated in the Northeast, but a national and even international health threat, with cases in Switzerland, the U.K., and even China.
Rabbit B4 developed no cavitary lesion but notable granulumatous disease isolated to the bilateral upper lobes was appreciated.
However, it is reported that amongst clinical signs for systemic disease isolated candiduria may be the only indication for candidaemia.
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The standard epidemiologic response to smallpox is to identify the disease, isolate cases, vaccinate everyone known to have had direct contact with infected people since the first week of symptoms and then monitor their state of health.
"I am skeptical about the completeness of the evolutionary story when it is based exclusively on the remnants of human disease isolates".
Group 2 accounts for 30/49 (61.2%) of the disease isolates but only 46/141 (32.6%) of the carriage isolates.
In contrast, 67.4% of the carriage isolates and 38.8% of the disease isolates correspond to Group 1b.
ST88 is the most convincing case, accounting for 14% of the disease isolates and>1% of the carriage isolates.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com