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The onset of disease is not manifested clinically and little is known regarding the cause of non-familiar AD.
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It is also possible, although unlikely, that these animals had recently become infected, and PV induced disease was not manifested at the time of death.
Another problem of our approach is that it relies on gene expression data alone; therefore it may fail to match disease and drug effects that are not manifested at the gene expression level.
Accordingly, we selected the following time points: 1) immediately after birth (PND 0, i.e., <24 hours), when the transgene is overexpressed but disease is not yet manifested histologically; 2) at PND 3, when tracheal mucus obstruction is prominent; 3) at PND 10, when chronic lower respiratory disease is being initiated; and 4) at PND 42, after establishment of chronic pulmonary disease.
I am not manifested on a flight today.
Its expression was not manifested in normal urothelial cells.
Given that hearts are the most mitochondria-rich organ, and indeed will only contract for a handful of cycles after interruption of mitochondrial ATP production, it seems paradoxical that cardiac disease is not more commonly manifested in primary mitochondrial disorders.
The Trans teen, child or adult is manifesting gender; they are not manifesting sexuality.
The physiological mechanisms that mediates stress and their contribution to illness and manifest disease is not fully understood.
Primary prevention targets those in whom the disease is not yet present, with the aim to provide interventions to prevent the disease from manifesting.
"Disease is not required.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com