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Thus, the role of HLA-DQB1*06:02 in disease initiation should be further elucidated.
Synovial fluids were harvested at the peak of the disease (day 8 after disease initiation).
Colon cancers are characterized by aberrant gene expression signatures associated with disease initiation and progression.
Dettmer U, Newman AJ, Soldner F, et al. Parkinson-causing alpha-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.
The highly crossreactive SA138 rapidly reversed inflammation and improved disease outcome with nearly 60% reduction of clinical score and 0.3 mm of ankle thickness over control at the peak of the disease (day 8 after disease initiation).
Animal models recapitulating post-traumatic osteoarthritis (OA) suggest that subchondral bone (SCB) properties and remodeling may play major roles in disease initiation and progression.
Genetic and biochemical studies have shown that RAS signaling mediated by KRAS plays a pivotal role in disease initiation, progression and drug resistance.
Such molecular network, promoting disease initiation and acquisition of a proinvasive phenotype, highlights new options to design multitarget therapeutic strategies for PTCs.
These data provide a window into the ways in which the n-3 PUFAs may impact disease initiation, progression, and resolution.
Here we report the development of a fully orthotopic, humanized in vivo model for melanoma, faithfully recapitulating human disease initiation and progression.
From the perspective of systems biology, this can have implications for the activity of entire regulatory networks, and recent studies have even suggested that aberrations in mRNA stability can play a role in disease initiation and progression.
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