Thus far, antibody mixtures are being used mostly for oncology and infectious disease indications.
Leukemia is the most common cancer subtype and accounts for 57.4% (n = 120) of disease indications.
There are many versions of adaptive enrichment proposed across many disease indications.
Ligands specific for B7.1 (CD80) and B7.2 (CD86) have applications in disease indications that require inhibition of T-cell activity.
Both agonists and antagonists of TLR4 are of considerable interest as drug leads for various disease indications.
Verapamil (MW 454.6) is a Ca++-channel blocker with multiple disease indications (implying considerable promiscuity, consistent with a log P value of 3.79 http://www.drugbank.ca/drugs/DB00661).ca/drugs/DB00661
These agents may expand the clinical utility of proteasome inhibitors for the treatment of solid tumors and for specific non-oncological, i.e., inflammatory disease, indications as well.
We believe that with increasing drug-target interaction dataset RepTB will be able to offer better predictive value and is amenable for identification of drug-repurposing candidates for other disease indications too.
Thus to illustrate the enigmatic roles of type I IFNs as immunomodulators or immunosuppressors requires further work on, but not limited, delivery sites, regulating mechanism, optimal dosages and schedules of type I IFNs, and disease indications and circumstances.
Preventive and therapeutic vaccines for infectious disease indications are regulated by the Office of Vaccines Research and Review in the Center for Biologics Evaluation and Research CBERR) within the U.S. Food and Drug Administration FDAAdministration FDA
Hybrid nitrates and NO chimeras, respectively, release a non-nitrate drug molecule or contain an ancillary pharmacophore; both approaches are designed to amplify or synergize the therapeutic activity of the nitrate in specific disease indications.
