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Although most of the initial studies have been focused on ovarian cancer, the disease indication for the current clinical trial includes all solid tumors [ 35].
Data on age, gender, etiology of liver disease, indication for ICU admission, length of ICU stay, and in-hospital mortality were available for all patients.
We collected all relevant data and information, including patient's age and disease, indication for PICC insertion, duration of the dwell time for the device, incidence of complications at insertion or during maintenance, and cause of removal.
Concerning risk factors, which were found previously in other studies, the presence of pre-existing valvular disease, indication for endocarditis prophylaxis, and immunodeficiency did not differ significantly between the groups in our study.
A principal strength of this study was that the eye disease indication for use or non-use of immunosuppression was a non-lethal disease, overcoming the causal pathway of indications-for-treatment bias as effectively as possible outside a randomised trial, which is not a feasible study design option to address this question.
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This approach was taken with the implicit hope that methods which predict drug classes well will also do better at predicting disease indications for drugs.
This has suggested unexpected relationships among receptors, identified targets active in phenotypic screens (58), and predicted off-targets and new disease indications for drugs (40).
Furthermore, by programming a menu-selection for SBP, our hospital - or any hospital with similar capabilities - may track the disease indications for each antibiotic allowing for audits and outreach.
These conclusions should be generalisable to other disease indications for immunosuppressive treatment unless a disease-treatment interaction that increases the risk of death exists for other diseases, which seems unlikely.
A mechanism to control for disease indication that led to treatment is needed for a study such as this.
These findings have led to cellular engineering to enable the production of selected glycoforms of antibody that are considered to be optimal for the disease indication to be treated.
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