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These findings have led to cellular engineering to enable the production of selected glycoforms of antibody that are considered to be optimal for the disease indication to be treated.
Our understanding of structure/function relationships is such that we can contemplate engineering the IgG Fc to enhance or eliminate biologic activities to generate therapeutics considered optimal for a given disease indication.
PRVs for NTDs are granted if a pharmaceutical company obtains approval from the Food and Drug Administration FDAA) for a drug or vaccine for a neglected disease indication.
"If we can build up and understand mechanisms on the molecular level, we can better design drugs and therapies for a particular disease indication," Spangler says.
"If we can build up and understand mechanisms on the molecular level, we can better design drugs and therapies for a particular disease indication," says Jamie Spangler.
In each specific disease indication it is critical to assess which strategy is most appropriate and many factors need to be taken into consideration.
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Small-molecule compounds continue to be developed and prescribed, improving life expectancy across several disease indications.
Cheng, J., Yang, L., Kumar, V. & Agarwal, P. Systematic evaluation of connectivity map for disease indications.
Leukemia is the most common cancer subtype and accounts for 57.4% (n = 120) of disease indications.
There are many versions of adaptive enrichment proposed across many disease indications.
Drug disease indications were obtained from the Cortellis Clinical trial records and mapped to MedDRA SOC terms as described below.
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