Sentence examples for disease hallmark from inspiring English sources

Osteoarthritis (OA) is a highly prevalent degenerative joint disease, that involves the cartilage and the surrounding tissue, with the pain as the clinical disease hallmark.

However, critical aspects concerning this statement have been recently raised because the requirement for a disease hallmark appeared not to be met by lack of habituation[2, 3].

A disease hallmark should be intrinsic to the pathophysiology of a disease and as such ubiquitous or quite so and specific for that disease.

With this approach, we also avoid selecting genes that diverge from the normal-aged profile by causes other than AD, as we expect that the severity scale in AD has a higher probability of being correct in the "Severe AD" cases (since they have high values of NFT and low MMSE scores, clearly a joint combination highly appreciated as a disease hallmark).

Dysfunctional mitochondria are a well-known disease hallmark.

The possibility to map amyloid-beta, the Alzheimer's disease hallmark protein, in vivo opens the application for amyloid imaging in clinical trials with disease-modifying agents.

The mice recapitulate many of the disease hallmarks that are seen in patients with this mutation, including increased tau exon 10 inclusion in both mRNA and protein, motor and behavioral deficits, and tau protein accumulation in neurons and tufted astrocytes.

Moreover, it recapitulates major disease hallmarks, including locomotion defects, neuronal death and aggregate formation (Chai et al., 2008).

Curcumin diet also reduced astrocytosis, microgliosis, and lymphocyte infiltration as well-known disease hallmarks in Plp1 transgenic mice.

Suppression of hnRNP A/B due to impaired cholinergic signalling may directly cause key disease hallmarks (Fig 6F).

Disease hallmarks are varying degrees of villous atrophy, crypt hyperplasia, intraepithelial lymphocyte infiltrates and serum auto-antibodies [ 3].