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Rhinorrhea is a key symptom of allergic rhinitis and this disease feature is reduced by antihistamine treatment.
Should such an upregulation of TAS2R with asthma extend to other cells/tissues including ASM, this disease feature would further favor the use of TAS2R agonists as asthma therapeutics given receptor upregulation would help protect against receptor desensitization which is believed to limit the therapeutic efficacy of anti-asthma GPCR agonists, including the beta-2-adrenoceptor27,28.
A main problem of clinical phenotyping is that the definition is often biased, as mostly only the most dominant disease feature is used for classification [5].
(A) Colonic tissue specimens from CD patients with active disease feature a large amount of collagen fibers indicative for fibrosis as visualized by van-Gieson staining.
Despite the heterogeneity, it is likely that there is some genetic overlap, as all JIA subtypes share joint inflammation as the most prominent disease feature [1, 2, 3, 4].
Polyglutamine expansion diseases such as spinobulbar muscular atrophy and Huntington disease feature proteins that are destabilized by an expanded polyglutamine tract in their N-termini.
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But younger Americans who died from the disease did not show common disease features.
Class 2 disease features exclusively polycythemia, which has been previously described as ECYT4 (Table 1).
Characterization of patient-specific disease features at a molecular level is an important emerging field.
Since severity of disease features may be discordant within individuals, composite outcome measures are warranted.
However, MM is a heterogeneous disease, featured by various subtypes and different outcomes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com