In patients with pathological stage II and III disease, high expression levels of EphA2 and EphA4 were significantly associated with poorer DSS on univariate analysis (p = 0.019, p = 0.007, Figure 3).
The extent to which such assemblies are involved in human disease, where expression levels of both mutant and WT SOD1 protein are much lower than the mouse models, is likely to be dependent on the nature of the fALS mutation.
Note that traits refer to diverse biological outputs such as eye color, onset of diseases and expression levels of genes.
In many malignant diseases the expression levels of CD44 and its splice variant v6 (CD44v6) have been associated with the prognosis.
All members were more highly expressed in T2 disease, and furthermore expression levels between T2 and T3 disease showed a significant decrease for Lck, Lyn, Fyn, Blk and Yes (P=0.032).
They also demonstrated that high levels of miR-146a and miR-16 expression correlate with active disease, whereas low expression levels correlate with inactive disease [ 26].
Moreover, it was demonstrated that high levels of miR-146 and miR-16 expression were correlated with active disease, whereas low expression levels correlate with inactive disease [ 7].
Furthermore, we demonstrated that high levels of miR-146a and miR-16 expression correlate with active disease, whereas low expression levels correlate with inactive disease.
In stage 4 disease, Met expression level did not discriminate poor vs good 5-year overall survival indicating that in advanced stage OA other factors determine survival.
Nevertheless, the correlation between life expectancy or severity of disease and expression level of mutated β-MHC is an additional aspect in FHC genotype phenotype correlation and may represent a new prognostic parameter.
