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While this single activity may lead to suboptimal radiation doses in neuroendocrine tumors (NET) with advanced or bulky disease, dose escalation has been withheld due to concerns on potential tumor somatostatin receptor saturation with reduced efficacy of the added activity.
Only three variables, however, had a significant independent effect: lung disease, dose of prednisone and treatment with antimalarials at the study point, the latter showing a strongly protective effect.
In the case of patients with kidney disease, dose reductions are required in patients with a creatinine clearance (CrCl) of 30 to 50 mL/min because renal impairment prolongs the half-lives of NOACs, especially dabigatran.
The survey is conducted every trimester through a structured questionnaire to allow for data capture by each doctor and specific medical visits, patient demographics, week surveyed, type of disease, dose and amount prescribed (volume, formulation and dosage per diagnosis).
In addition, these studies used classifications of previous diabetes based solely on the clinical history and failed to control the analyses for confounding variables, which may greatly influence both hyperglycemia and mortality (e.g., degree of malnourishment, severity of disease, dose of carbohydrates infused, glycemic variability).
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For patients with intermediate-risk or high-risk disease, doses up to 81.0 Gy provide improved disease control as assessed by prostate-specific antigen (PSA).
But if it is 25 years or longer, the peak might be a decade or more away—and the present small number of cases would offer no guidance whatever on the eventual toll.Several factors besides genetics are known to affect the incubation period of prion diseases: Dose.
In other autoimmune diseases, doses of 20 mg (RA, PsA) [ 5, 6] and 30 mg (GPA) [ 8] were used in order to induce remission.
Given the low responses seen in relapsed disease, increased dosing and dose escalation have been evaluated as strategies to increase response to rituximab (Byrd et al, 2001; O'Brien et al, 2001).
also reported 50 55% stable disease with dose escalation 4. Their study also found that dose escalation also controlled abdominal pain in metastatic disease.
In our study, two patients among those who achieved prolonged stable disease had dose reduction to 2 mg m−2 after initial cycles, suggesting that clinical benefit may also occur at a dose lower than the recommended 4 mg m−2.
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CEO of Professional Science Editing for Scientists @ prosciediting.com