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The antibodies produced by autoreactive or polyreactive PCs in the BM are often not pathogenic; however, they may be predictive of later disease onset in some individuals, indicating that additional factors beyond autoAb production are required for disease culmination [ 37].
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Henry Dale described it as an exemplar of 'a complete and systematic investigation of a virus disease', and its culmination in the large-scale production of a vaccine symbolized the importance of the NIMR to the nation.
The Water Test, on this cover of Emerging Infectious Diseases, is a culmination of Day's Native Indian and artistic philosophy: everything is interconnected and imbued with spiritual energy that can be positive or negative.
This is despite the fact that cervical cancer is amenable for early detection due to its long and relatively well-known natural history prior to its culmination as invasive disease.
These stages start with premalignant atypical ductal hyperplasia (ADH), which may progress to preinvasive ductal carcinoma in situ (DCIS), followed by a possible progression to invasive ductal carcinoma (IDC) and culmination in metastatic disease [ 2].
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Finally, AF and LV dysfunction may be the culmination of common cardiovascular conditions such as hypertension or coronary artery disease, and could be considered 'chamber-specific expressions' of global myocardial damage.
The effect on overall HRQoL is likely to be a culmination of factors that, due to smaller numbers of non-epithelioid disease and complex symptomatology, this analysis cannot detect.
The increasing prevalence of AF in an ageing population, in conjunction with slowly progressing conditions such as hypertension, coronary artery disease (CAD), obesity and heart failure, suggests that AF itself may be the culmination of a protracted process.
In this paper, the culmination of 11 years of research into the immunological characteristics of this disease in a group of 221 VKC patients will be presented.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com