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One of the major aims of the population approach is to distinguish and characterize patient and disease contributors to inter-individual variance in drug pharmacokinetics.
Cognitive impairment and dementia, whose prevalence double with every five-year incremental age increase, are the leading global chronic disease contributors to older persons' disability and dependence [ 5].
Identifying and independently varying critical cellular and molecular disease contributors is difficult in animal models, but in microfluidic systems, molecular factors and different cell types can be varied independently and simultaneous measurements of real-time system-level responses become practical (Benam et al. 2015; van de Stolpe and den Toonder 2013).
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HOCl plays a role as a microbicide in immune systems but, on the other hand, is regarded as a disease contributor.
Dementia emerged as by far the leading independent chronic disease contributor to dependence.
This low contribution can also be related to the fact that dementia and Alzheimer disease, important contributors to the disability burden in the elderly, were not included in this disease group due to lack of availability in the four HIS.
Both toxins as the main disease-causing contributors are exploited as antigens in the vaccine development against tetanus and diphtheria (Alpar et al., 2001).
Increased cIMT has been widely used as a reflection of preclinical atherosclerotic disease, a contributor to the development of hypertension.
Coral diseases are contributors to the global decline of reefs, and there is a perception that these often act synergistically with other stressors in bringing about coral mortality (for example, [ 1]).
These chronic diseases are major contributors to the steadily increasing human disease burden and to the escalating cost of health care throughout the world.
These findings indicate the freeways and disease are important contributors to genetic diversity and differentiation in bobcat populations in SMMNRA.
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