Sentence examples for disease contexts from inspiring English sources

Here, we discuss current efforts to design and optimize gene therapy strategies to improve ER proteostasis in different disease contexts.

This suggests that a primary defect in CFTR expression is not the root cause of neutrophilic inflammation in these disease contexts.

Crystal structure analysis has provided a detailed understanding of the catalytic mechanism, and rhomboids have been implicated in various disease contexts.

The interactions between PGRN and TNFR have been demonstrated by many laboratories in multiple disease contexts, indicating that the balance of TNF-α/PGRN is crucial to the development of these diseases.

Remarkable advances of biological understanding have been made on the complex roles of reactive oxygen/nitrogen species (ROS/RNS) both as signaling molecules and pathogenic contributors in health and disease contexts.

While TLX is in the process of escaping from orphanhood, future ligand design needs to progress in parallel with improved understanding of (i) the binding cavity or surfaces to target with small molecules on the TLX ligand binding domain and (ii) the nature of the TLX coregulators in particular cell and disease contexts.

These disease contexts thus may impose a skewed interpretation of in vivo hematopoiesis derived from retrovirally gene modified cells.

Finally, effects of retinoids on AKAP12β expression should be evaluated in other disease contexts where cell proliferation is manifest (e.g., cancer).

Our results establish AKAP12β as a novel retinoid-responsive tumor suppressor gene, making it an attractive target for therapy in a variety of disease contexts, including vascular occlusive diseases.

This assay may also be utilized to detect surface antigens in a range of cell types, and thus may be adapted to monitor the B cell-derived antibody repertoire in different disease contexts.

It is interesting to observe that some of the differentially expressed genes in this study have been discussed in other Treg gene expression studies, in both the physiological and disease contexts.