"disease context" is a correct and usable phrase in written English.
It refers to the specific background or circumstances surrounding a particular disease. It can be used when discussing a certain disease or condition and its impact on a person or population. Example: In order to fully understand the spread of COVID-19, it is important to examine the disease context, including factors such as age, underlying health conditions, and population density.
Instead, it was located together with pathological misfolded proteins in autophagosomes.107 Thus discerning the autophagy process role in a neurodegenerative disease context could prove quite complex.
Here we discuss current efforts to design gene therapy strategies to alleviate ER stress on a disease context.
Within this disease context, ATRX deficiency invariably co-occurs with mutations in TP53 and in genes encoding either isocitrate dehydrogenase enzymes (IDH1 and IDH2) in adults or H3.3 histone monomers (H3F3A and HIST1H3B) in children.
Whether these activities impart a disease-resolving and/or contributory outcome depends at least in part on the disease context, stage of pathogenesis, and cellular milieu in which these factors are released.
"While the numbers are still small numbers, we are starting to put this research into the real disease context and get something out of it," says Jay Shendure, a geneticist at the University of Washington in Seattle, and a TR35 winner in 2006.
A framework for annotating human genome in disease context.
Cumulatively, these findings indicate that the pharmacological inhibition or activation of the Hippo pathway could be desirable depending on the disease context.
Although ELSO issued guidelines on the use of ECMO in patients with ARDS, these guidelines do not address specific disease context, and are difficult to generalize to the heterogeneous ARDS population.
In summary, we demonstrated here that integration-free iPSCs can be efficiently and consistently obtained from non-invasively acquired human EMCs and UCs, even in a defective disease context (i.e. type II DM) (Fig. 1L).
We also proved that cells reprogrammed through this strategy maintained genomic integrity even in a compromised disease context, as FA patient cells have a defective DNA repair system (Liu et al., 2014; Raya et al., 2009).
Collectively, these data present a comprehensive profiling of EBV miRNAs in a disease context and implicate their pathological significance.
