Generally, drawing cause-disease conclusion based on PCR sequencing needs vigilance to satisfy the modified Koch postulates (5 ).
Similar to most qualitative research in rare diseases, conclusions drawn from the current study are based on a small sample size, particularly with respect to the number of physicians interviewed.
Genetics play a vital role in the development and progression of the disease, a conclusion which is supported by family cohort studies and ethnic based variations in its incidence and presentation (Anstee and Day, 2013).
Further, while in the present study, measurement of stroke volume by thermodilution has been found to be accurate as compared to left ventricular angiography in obstructive and dilated heart disease, a conclusion cannot be reached regarding valve regurgitation based on the data presented.
An effort to integrate both ecological and evolutionary responses of hosts, vectors and their pathogens will improve management of Lyme disease; a conclusion that likely extends more generally to the effects of diseases on wildlife (e.g., Vander Wal et al. 2014).
An anti-CAG development program may address multiple diseases, a conclusion previously reached by van Roon-Mon and colleagues.
We should consider some limitations: the study is confined to a single disease, so conclusions drawn from its results may not be generalisable to other diseases.
The different microRNA patterns are not intended to draw any disease specific conclusions and shown only as a proof of concept.
COMMENT: ""classes diseases" in Conclusion paragraph" RESPONSE: As rightly pointed out by the reviewer, we have corrected the above text in the manuscript.
This study provides novel insight into the efficiency of common tendinopathy treatments for arresting and reversing degenerative structural changes in the initial stages of disease Limitations: Conclusions regarding the efficiency of these treatments is limited by the short timescale of the follow-up sample collection.
In order to draw indication and disease-specific conclusions, the results were divided into the following areas: malnutrition, gastrointestinal surgery, cow milk protein allergy (CMPA), and others.
