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Farh et al. [ 50] developed a method for estimating which SNPs are most likely to be causal, based on dense genotyping data obtained using a specialized immune disease chip, and then extrapolating to other complex traits.
At least part of the answer to these problems lies in the development of custom genotyping chips such as the Immunochip designed for immunogenetics studies, the Metabochip designed for studying metabolic diseases, and a cardiovascular disease chip [ 7].
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In a wide-ranging interview, Frazier talks about meeting Sly Stallone before Rocky II, while Foreman makes self-deprecating wisecracks and Ali, his words slowed by Parkinson's disease, chips in with wry asides.
The most widely used are the specific-disease chips for different types of RD.
All antigens and antibody pairs on these chronic inflammatory disease (CID) chips were developed by Roche Diagnostics.
Here, we typed African American samples with the dense immune disease SNP chip, ImmunoChip, with over 5000 SNPs in the HLA region 12 (http://www.immunobase.org), performed classical HLA class II typing, and adjusted for ancestry using principal component analysis.
Only an RNA-based cell cycle progression score (Cuzick et al, 2011, 2012), extent of disease (% chips) (Rajab et al, 2010a) and the immunohistochemistry (IHC) proliferation biomarker Ki-67 (Berney et al, 2009) provided substantial improvement on assessment of prognosis based on Gleason score and PSA alone.
' Candidatus Liberibacter solanacearum' (Lso) is a phloem-limited alphaproteobacterium associated with the devastating zebra chip disease of potato (Solanum tuberosum).
These results provide new insights into the role of bacterial flagellin in the development of potato zebra chip disease.
Our findings provide new insights into the role of the Lso flagellin in the development of potato zebra chip disease and potential application in breeding for resistance.
The putative causal agent of Zebra chip disease is ' Candidatus Liberibacter solanacearum' (Lso) (also known as Ca. Liberibacter psyllaurous), which is transmitted by the potato psyllid, Bactericera cockerelli[ 3],[ 5].
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