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By providing additional functional information and in the correct setting, FDG PET-CT can allow earlier detection of tumours, identification of occult metastatic disease, characterisation of indeterminate lesions, assessment of therapeutic response and overall more accurate staging for potential resection.
The demographics and disease characterisation of the patients and controls are shown in table 1. Biopsies were obtained from the sigmoid colon.
However, the lack of biomarkers and the fluctuating nature and lack of specificity of symptoms makes disease characterisation and disability assessment challenging.
These results are in contrast to previous findings that indexing with PBW improved disease characterisation and correlations with survival [ 2- 4].
Focal liver disease characterisation will be of great benefit once multivoxel methods with fat suppression are implemented in proton MRS, in particular on high-field MR systems providing gains in signal-to-noise ratio and spectral resolution.
Despite this paucity, there are studies that report the potential of DW- and DCE-MRI biomarkers for disease characterisation [ 25, 26] and response assessment in various paediatric oncological settings.
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Impact was divided into: (1) major detection of occult disease or characterisation of indeterminate lesion(s) on CT/MRI; (2) minor confirmation of suspected metastases seen on CT/MRI; (3) no impact.
This study shows that FDG PET-CT has a significant clinical impact on management decisions in patients with stage III/IV MM through the detection of additional sites of distant metastatic disease and characterisation of indeterminate findings on CECT, which can alter or preclude potential surgical or chemotherapeutic management.
From the same challenge experiment, a significant proportion of the infected fish did not develop cardiac pathology, providing an opportunity for a comparative study of individuals with different outcomes of disease and characterisation of the underlying molecular mechanisms associated with protection versus pathology.
A major clinical impact was defined as a change in treatment plan resulting from identification of additional sites of disease or by characterisation of indeterminate findings on prior imaging.
A major clinical impact was defined as a change in treatment plan, e.g. radical surgery to systemic chemotherapy resulting from identification of additional sites of disease or by characterisation of indeterminate findings on prior CECT imaging.
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