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Mutation Taster indicates this variant to be disease causing with a probability of 99 % and PolyPhen-2 envisages damaging consequences (prediction sensitivity 0.83/specificity 0.83/specificity
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Furunculosis, a disease caused with gram negative bacteria Aeromonas salmonicida produces heavy losses in aquaculture.
Trends were apparent for deaths from cardiovascular causes and respiratory disease causes with the greatest magnitude of difference for respiratory causes but not significant for deaths from cancer or other noncardiovascular nonrespiratory underlying causes.
This categorization was based on the assumption that variants with high frequency would be less likely to be disease causing compared with variants of very low frequency.
One variant was classified as "DM?" (likely disease causing but with questionable pathogenicity) in HGMD and not reported in ClinVar.
On the other hand, p.Thr2250Met mutation is described as disease causing mutation with medium risk in Human Gene Mutation Database (HGMD) Professional 2012.3.
Brief stimulation of PC12 cells expressing the disease causing Rab7 Cmutantstants with NGF did not significantly affect Akt phosphorylation.
The overcrowded prison was overrun with disease, causing the death of more than 1,300 inmates.
Therefore, social mobility may be health-related, with disease causing downward social mobility.
Take it in stride, and know that everyone comes in contact with these disease causing agents.
Foot-and-mouth disease causes blisters with an infectious discharge in the mouths and on the extremities of cattle and pigs, provoking loss of appetite, high fevers, and ultimately death -- often to entire herds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com