Alternatively, the diffusion changes seen on MRI might not be directly related to histopathology, but could be due to prion disease causing impairment of functional processes in brain cells, such as altered ion channel function due to decreased plasma membrane fluidity (DeArmond et al., 1996) or impaired axonal transport (Liberski and Budka, 1999).
Their political activism was vital to their professional formation: they loathed the invasive, depletive practices of traditional medicine and protested against medical procedures that addressed symptoms rather than disease causes while resisting processed foods, pharmaceuticals, environmental toxins, and atomic energy.
This issue is particularly relevant for neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), an adult onset motor neuron (MN) disease caused by pathological processes occurring in both neuronal and non-neuronal cells.
X-linked adrenoleukodystrophy (X-ALD; Phenotype MIM number #300100), the most frequent monogenetically inherited peroxisomal disease, causes demyelinating and neurodegenerative processes in the nervous system (1– 3).
Multiple sclerosis is an autoimmune disease caused by an inflammatory demyelinating process that affects multiple white matter tracts within the CNS.
Konzo is a neurotoxic motor disease caused by excess consumption of insufficiently processed cassava.
Sex is defined 'in terms of biological difference, whereas gender refers to economic, social and cultural attributes.' 16 CVD refers to a disease caused by a series of pathological processes in which the coronary arteries gradually thicken and harden, leading to atherosclerotic plaques that impede or occlude coronary and other vascular blood flow.
Protozoal disease, disease caused by protozoans.
Do these cells initiate the disease-causing process?
It is now possible to explore the pathway, they say, in the hope of devising treatments to correct the disease-causing process.
Apart from a high proportion of non-genetic forms, even familial DCM shows a high degree of genetic heterogeneity, with different subcellular systems being involved in the disease-causing process [ 16].
