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Comprehensive investigations revealed positive testing for HLA-B51, raising the suspicion of a Behçet's disease background.
Several other causative factors have been reported to clarify this discrepancy either related to the disease background or the workflow of biomarker development.
Most studies focusing on pathophysiology utilize young animals, without any cardiovascular disease background, even though these animals are clearly not reflective of the pathophysiology of the patient populations.
The common failures to translate promising preclinical drug candidates into clinical success and the endeavors to realize precision medicine highlight the urgent call for a model system with easy accessibility, high physiological relevance and ability to incorporate patient-specific disease background.
Moreover, the derived 370A allele results in increased activation of NF-κB compared to the ancestral 370V allele on both the normal (p = 0.018, univariate ANOVA with experiment as a random factor and clone as a fixed factor) and the disease background (p<0.004, two-tailed t-test assuming equal variances; Figure 3).
The response to moxifloxacin treatment was broadly independent of the patients' demographic and disease background.
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However, there still exists limitation of these markers in the diagnosis of cardiovascular conditions, because they can be affected by CAD-unrelated environmental factors and disease backgrounds [ 55].
Whether or not there is room for improvement, however, our SCCA-1 data clearly indicate that as we come to consider further candidate biomarkers it is important to assess HCC arising in different disease backgrounds independently when performing validation studies.
Fortunately, because major lipoproteins on HDL are smaller than 30 kDa, MALDI-TOF is quite suitable for revealing expression changes of major HDL lipoproteins and their isoforms in different disease backgrounds.
Antimicrobial resistance fact sheet from the National Institute of Allergy and Infectious Diseases Background on antibiotic resistance from the Food and Drug Administration Genesoft corporate profile.
The former is basically an attempt to maintain the frequency of disease near background; the latter relates to reducing the frequency of disease below background (i.e., improving the health of the general public).
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CEO of Professional Science Editing for Scientists @ prosciediting.com