Sentence examples for disease aggregation from inspiring English sources

Sources of familial disease aggregation other than the gene under study result in overestimates of the penetrance in mutation carriers, underestimates of penetrance in non-carriers, and overestimates of allele frequency.

They analyzed the spatial distribution of this disease by using Ripley's K [31] [32] as a measure of disease aggregation.

However, most such associations are weak and account for only a small fraction of familial disease aggregation [ 1].

However, it should be kept in mind that, in the first stages of disease, aggregation may even act in a protective manner.

Exome sequencing was performed in 43 patients with colorectal cancer from 29 families with strong disease aggregation without mutations in known hereditary colorectal cancer genes.

Exome sequencing in 43 patients with CRC from 29 families with strong disease aggregation identified new potential CRC predisposition variants in CDKN1B, XRCC4, EPHX1, NFKBIZ, SMARCA4, and BARD1.

If the levels of susceptibility differ between the species we observed or between genotypes, and if species or genotypes with high susceptibility tend to grow relatively close to each other, this could also contribute to disease aggregations.

In Alzheimer's disease (AD) aggregation and accumulation of the amyloid β (Aβ) protein and microtubule associated protein tau (MAPT) have both been implicated as key pathogenic 'triggers' [ 5].

Comorbidity was measured in different ways in the studies under review, referring either to one specific disease or aggregation of several diseases using an index.

Our compounds freely penetrate the blood-brain barrier [ 56] and apparently target different levels of the pathologic cascade of Alzheimer's disease inhibiting aggregation and proteo-toxicity while restoring normal neural metabolism and regeneration.

The presentation of CRAO in a young individual is associated with a variety of medical conditions, including hyperhomocysteinemia, temporal arteritis, systemic lupus erythematosus, sickle cell disease, platelet aggregation abnormalities, and migraine.