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The high prevalence of myocardial inflammation may reflect increased disease activity and/or high disease affinity for heart in those who are resistant to induction therapy.
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The lack of LAM antigen detection in the majority of TB pleural effusions probably reflects the pauci-bacillary nature of pleural disease, though high affinity antigen-antibody binding cannot entirely be excluded.
The mutant TRIM18 proteins with the C-terminal region that are produced in this disease show decreased affinity for microtubules.
12 Impaired binding of IgM/IgA-NMDAR antibody-positive serum to rat brain sections (using routine procedures for IgG detection) further suggests that disease mechanisms, antibody affinity, and epitopes are different between IgG-positive anti-NMDAR encephalitis and IgM/IgA-associated cognitive decline.
Some disease processes have selective affinity to temporal lobe due to selective limbic system vulnerability, which might be immune mediated, as in limbic encephalitis [5].
However, Choline is not specific for prostate cancer either in intra prostatic or extra prostatic disease and a high affinity of the radiopharmaceutical has been evidenced by benign hyperplasia.
The Lyme disease spirochete has an affinity for the CNS (Rupprecht et al., 2008).
A prior study suggested that disease mutations reduce nucleotide affinity, impair Rab7 GTPase activity and lead to constitutive activation (21).
Surprisingly, we observed that the HGF profile was similar to that in acute inflammation; in the CSF from patients with Alzheimer's disease, the HGF binding affinity to HSPG was significantly higher than in the samples from all other groups, except for the samples from patients with community-acquired septic meningitis (Table 1).
It has long been recognized that many dying and dead neurons, seen in a variety of diseases, exhibit an increased affinity for various silver stains (argyrophilia [22]].
A better understanding of the uptake processes may also have therapeutic benefits as some inherited diseases feature reduced flavin affinity to the affected flavoproteins and thus are potentially treatable by riboflavin supplementation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com