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This remains a major gap in the current work that should be discussed in a revised version.
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This difference and its potential implication in the activation mechanism are discussed in the revised manuscript in a speculative manner.
This result is discussed in the revised Discussion.
The Met 27 experiment and considerations about molecular mechanisms of Met/Gce action are discussed in the revised Discussion under "Hormonal remodelling of adult organs".
As discussed in the revised text this indicates a single, linear kinetic pathway for wrapping, consistent with the energy landscape proposed.
During the past month, we carried out experiments to directly test this idea, and the new data are presented in a new Figure 6 and discussed in the revised text.
As discussed in the revised text, the analysis of a newly available dataset of human acetylation sites [ 33] did not confirm our initial observations.
Moreover, as discussed in the revised text, sets including only closest non-modified serines provide an even better control for artifacts that could be caused by specifics of regions surrounding modification sites.
This is discussed in the revised manuscript.
Again, this is appropriately discussed in our revised manuscript.
These caveats are discussed in the revised manuscript.
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