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The advantage of higher doses is clearly evident for patients in the intermediate prognostic group, but is still discussed for patients with a low risk tumour or treated in combination with hormone therapy.
A transjugular intrahepatic portosystemic shunt should be discussed for patients with less advanced SOS/VOD and hepatic transplantation in most severe diseases.
If the high prognostic value of p53 mutations in superficial bladder cancer is confirmed in larger prospective trials, more aggressive therapeutic strategies could be discussed for patients with p53 mutations in their tumour specimens.
It is of note that all prior leading-edge biopsies taken before the day of patient A's presentation were analyzed with the same primers about to be discussed for patients A, B, and C. The patients will be referred to as patients A, B, C, and D in this discussion, and biopsies taken from them referred to as biopsies A, B, C, and D respectively.
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This point should be specifically addressed in a larger prospective study and a larger antibiotic spectrum discussed for patient with an initial severe clinical presentation notably after cardiac arrest and a high drowning grade.
Based on currently available data, PORT should be discussed for fit patients with completely resected NSCLC with N2 nodal involvement, preferably after completion of adjuvant chemotherapy or after surgery if patients have had preoperative chemotherapy.
Although the interpretation of mortality or severity of illness scores has been discussed for individual patients, higher values indicate a greater illness burden.
Of particular concern is the fact that the issue of multiple comorbid conditions is rarely discussed for older patients in the Canadian guidelines despite the strong association between aging and the presence of multiple chronic conditions [ 3- 5].
On the other hand, more intensive therapy could be discussed for other patient subgroups, such as older patients with a localised but unresectable tumour, with a type 2 profile.
Since these patients are usually younger and have a better prognosis, desintensification of treatment is currently being discussed for this patient group [ 19, 20].
One study provides support for the use of a ward round checklist on an adult ICU with increased attention to the issues that the team felt needed to be discussed for every patient every day [ 12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com