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However, our results combined with other studies discussed below, suggest that some epithelial tumors or hyperplasias do not carry activating mutations in Kras because of selection for other mechanisms that upregulate Kras activity.
While the effects as discussed below suggest the possibility that this novel mutation is pathogenic, the genetic support is inconclusive.
A number of recent lines of evidence, discussed below, suggest that WRN is potentially one such factor.
These findings, as will be discussed below, suggest that only a small fraction of the total protein produced attained its proper active conformation.
Our results, similar to other studies discussed below, suggest that the air pollution-associated acute changes in HRV parameters (increased or reduced) that have the highest potential for increasing the likelihood of a subsequent cardiac arrhythmia remain to be determined.
Although it is not clear yet whether these localization differences signify functional specialization, biochemical studies to be discussed below suggest that even the closely related LePRK1 and LePRK2 are likely to be differentially involved in their capacity to interact with signals from the female environment.
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This would be consistent with our functional data discussed below suggesting that NO might play a role in odorant adaptation.
Moreover, the axonal phenotypes of nrd−/− embryos discussed below suggested that the motoneurons were inactive early in embryogenesis.
The decreased maximal voluntary torque with unchanged, maximal voluntary activation (discussed below) suggests that the loss of muscle mass (decrease in CSA) was the dominating factor.
Nevertheless, the deep evolutionary conservation of Ig domain structures (38), together with our mass spectrometry data discussed below, suggests that the main features of our model are likely to be correct.
Secondary contact could also result in a bimodal distribution of phenotype, but cichlid ecology, a single colonization event and no genetic evidence for secondary admixture (discussed below), suggests this is not the case in Apoyeque.
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