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Discriminant analysis suggested that the best discrimination between groups was achieved using a combination of ECLiPS factors, together with nonverbal Intelligence Quotient (cognitive) and AP measures (i.e., dichotic digits test and frequency pattern test).
In this way their contributions to the discrimination between groups do not overlap.
We determined that a nNUF value of 0.25, at the right side of the nNUFTI curve, provided the greatest discrimination between groups.
MicroCT analysis (2D and 3D) correlated well with the histological measurements, although more variability and less discrimination between groups was seen, with no statistically significant differences with alendronate treatment.
Although ROIs selected with this method provide a good discrimination between groups used in these specific studies, they might show significantly reduced discrimination power when applied to new data sets.
DFA determines n functions, (where n is the smaller of the number of groups-1 or the number of variables), in a way that the first function provides the most overall discrimination between groups, the second provides second most, and so on.
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Within-group variation in the label confounds discrimination between group members and non-members by increasing the potential for overlap with the labels of other groups [5], [17].
Table 4 provides the metabolite ratios that have the strongest effect on discrimination between group pairs.
Examination of PC3 identified hypotaurine as a further metabolite of interest, which provided good discrimination between group 1, where it is very low, and group 2, where it is particularly high (results not shown).
Inappropriate referencing of brain-derived proteins to their serum concentration using the CSF/serum quotient instead of the absolute CSF concentration leads to a loss of sensitivity for discriminations between groups, i.e., eventually to false interpretations of CSF data and disease pathologies.
Second, there should be discrimination between stage groups; patients in different stage groups should have larger differences in survival.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com