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We also tested separately for interaction between- and within-families genetic effect and age, sex and location (rural/urban) as effect modifiers in the models for quantitative traits.For association analysis with the discrete trait of type 2 diabetes, we used a mixed logistic regression model using the same Fulker's decomposition of genotypes on 561 sib pairs (see ESM Table 4).
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This study aimed to compare predictive performance of the linear, radial, polynomial and sigmoid kernel-based Support Vector Machine (SVM) in different scenarios of genetic architecture of a discrete trait (number of quantitative trait loci (QTL) and distribution of QTL effects) as well as heritability level.
Non-astringency is a discrete trait for the CPCNA fruits, but is a quantitative trait for non-PCNA fruits.
Among other limitations, cladistic practice in archeology emphasizes discrete traits to the virtual exclusion of continuous ones, which alters the character of data and might influence results.
We used combined discrete-continuous bivariate modeling analysis [ 27] to determine the environmental and genetic correlations between smoking (as a discrete trait) and expression of any given transcript (as a quantitative trait).
The discipline has heretofore focused on the molecular basis of evolutionary novelty among distantly related organisms [ 35, 56] or the genetic/transcriptional basis of discrete trait loss among closely related groups [ 51, 57].
An example appeared at the beginning of the unit (week 1), when few students could separate the notion of dominance (purple) and recessiveness (green) of the discrete trait (Mendelian marker) from the continuous gradation in anthocyanin pigment intensity as the quantitative trait.
However, analyses using the quantitative measure did validate the set of smoking-correlated transcripts identified using the more conservative discrete trait, with a tetrachoric correlation of 0.905 ± 0.012 between transcripts significantly correlated with each measure at a 5% FDR.
Although we did not require students to fully explain the mechanism of the discrete trait included as a "control" or Mendelian marker for the breeding schema, the majority of students were able to confirm and provide accurate explanations in their posters that the inheritance of the green plants in F2 populations was the result of segregating the anthocyaninless allele in a Mendelian 3 1 ratio.
This is in contrast to previous work where TBXO showed little improvement when the simulated model was an interaction contributing to a discrete trait in the complete absence of main effects [ 47].
The reassortment history of Eurasian AIV was inferred by discrete trait models (HA, NA and combined HA-NA subtypes) on phylogenetic trees.
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