A systems biology approach to immune system patterns can complement the traditional quest for discrete specificity.
Effects of IFNγ on IL-8 were not of unspecific nature but displayed discrete specificity since IL-1β-induced expression/secretion of COX-2 and IL-6 were left unaffected.
Compared to traditional inoculations with P. infestans isolates, the effectors also enabled the dissection of the activities of otherwise indistinguishable R genes into discrete recognition specificities, and moreover helped determine that Rpi-blb1 has two closely related orthologs in S. stoloniferum and S. papita.
Sequence similarity networks have been successfully used to organize functionally diverse enzyme superfamilies into subgroups and families of sequences representing discrete reaction specificities.
However, in contrast to the discrete immune specificity borne by individual T-cell or antibody-mediated immune reactions, recent attention has been directed to global patterns formed by collectives of low-titer antibody reactivities as indicative of immune-system state in both health and disease [1], [2], [3], [4], [5], [6].
The network that emerged from this study suggests the MAPK signaling cascade regulates transcription through combinatorial enzyme specificity and discrete phosphorylation events.
Thus, although all 3 polyserum exhibit similar titers of anti-HER-2 antibodies by ELISA using native protein, it is clear that each polyserum is composed of a discrete combination of individual antibody specificities.
To determine the effect of recombinant human erythropoietin (rHuEPO) therapy on five transfusion dependent, highly sensitized adolescents on dialysis, we serially measured percentage panel reactive antibody (%PRA) levels, titers of identifiable discrete anti-HLA Class I antibody specificities, and non-specific indices of cellular immunity before and following initiation of rHuEPO therapy.
Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity.
The results describe a pathway of transition from the GV to the MII stage that is punctuated of discrete recordable events showing their specificity and occurring with different time kinetics in the two types of oocytes.
