It is these tetrameric holoenzymes that are localized to discrete sites in the cell, typically by A Kinase Anchoring Proteins where they create discrete foci for PKA signaling.
Amino acid substitutions in skin prokineticins from the skin secretions of bombinid toads are confined to discrete sites affording the necessary information for structure/activity studies and analog design.
Altogether, the findings strongly suggest that neurosteroids do bind to discrete sites on the GABAA receptor and that these are located within the transmembrane domains of α and β receptor subunits.
We have discovered that Drosophila SAF-B binds to discrete sites on polytene salivary gland chromosomes, which largely overlap with RNA polymerase II.
A kinase anchoring proteins (AKAPs) are PKA binding proteins that localize PKA and other signaling molecules to discrete sites in many cells including neurons.
The redistribution of EGFR to discrete sites was specific to over-expression of ERβ and was not observed when ERα was over-expressed in these cells (Fig. 4D).
Together, these findings confirm that the PMLIb isoform predominantly localizes to discrete sites in the cytoplasm and to sites near or at the nuclear membrane, and that a physical association can occur between nuclear and cytoplasmic PML isoforms that can affect the localization pattern of both isoforms.
Rather, we analyzed CTCF at individual loci, because it binds to discrete sites.
TN-C expression is regulated by a number of mechanisms including growth factors, biomechanical force and ECM proteins, and discrete sites on the promoter region control these responses [ 5- 7].
Tetracycline binds to Mg2+ cations in order to pass through outer membrane porins and then, in the periplasmic space, dissociates from magnesium and moves passively into the cytoplasm to bind to discrete sites on the ribosomal 30S subunit [ 41].
In summary, the results obtained with C-terminally truncated actin support the view that, depending on the state of the thin filament activation, skeletal α-TM binds to discrete sites on actin.
