Leibniz held that space and time, as continua, are ideal, and anything real, in particular matter, is discrete, compounded of simple unit substances he termed monads.
By functionalization of the [Mo2S2O2]2+ precursor by oxalate, discrete compounds having open or cyclic structures as well as infinite solids were specifically designed.
This strategy combining library design and discrete compounds synthesis yielded inhibitor 35, that is highly selective for aggrecanases over a panel of metalloproteases and inhibits the degradation of native fully glycosylated aggrecan.
This recommendation applies whether the decision is a discrete compound-specific decision, such as setting an uncertainty factor or determining a benchmark dose, or a programmatic policy decision, such as adoption of a particular study design or method for particular types of testing.
Results obtained by these techniques have shown that the nonvolatile organic fraction of chlorinated drinking water consists of many discrete compounds.
Fischer's opinions were certainly not dominant at the time, but the colloid hypothesis did not die out until progress in enzymology and molecular biology replaced the homogeneous, gelatin-like description of the protoplasm by studying discrete compounds of life.
The PPh+4 complex 2 is a discrete ionic compound, while the compound [Na]trans-[Ru DMSO)(pyrazine)Cl4] · DMSO (3) crystallized with a molecule of DMSO.
The technique of combining polypeptide molecules and discrete coordination compounds thus makes it possible to design flexible, reversible, and spin-controllable metastable systems.
Application of structural alerts to the more than 33,000 discrete organic compounds of the EINECS inventory indicated 3585 chemicals (approx. 11%) as potential candidates for estrogenic and androgenic effects that should be further investigated.
