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This discrepancy strongly argues that multiple genome doubling events occurred during the evolution of the AA and AB subpopulations.
This discrepancy strongly argues for the importance of the patient's perspective, and suggests that physicians need to work closely with patients to gain a comprehensive assessment.
How can circulating Fgf15 (derived from the gut as currently often believed, and as also these authors claim) be crucial for liver regeneration, when FGFR4 has no role in liver regeneration 2? This discrepancy strongly suggests that the inability of the liver to regenerate in Fgf15KO mice is independent of FGFR4, and by consequence, must be explained by FGFR4-independent actions.
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This is probably because the discrepancies were symmetrical, as asymmetrical discrepancies strongly affected their perception in a previous study [35, 53].
Hence, such quite large discrepancies strongly suggest that, for more precise and reliable geodetic inversions of afterslip distribution, the surface displacement calculated for an inhomogeneous elastic medium with realistic subsurface structure, unlike the usual cases so far, should be used as the GFs.
These discrepancies strongly suggest that neither molecular model of DdP2XA is a fair representation of its native structure.
While some loci showed clear positive correlation between transcriptional activity and mRNA abundance, others revealed striking discrepancies strongly indicative of post-transcriptional regulation [ 10] and consistent with similar discordances seen in humans [ 11].
These discrepancies strongly imply that the molecular models of DdP2XA based on the zfP2X4.1 crystal structure are inaccurate; this is not surprising given the low degree of amino-acid sequence identity between the two receptors (16%), and the fact that the accuracy of homology modeling is dependent on sequence identity.
Such a discrepancy is strongly diminished when looking at the genome of the related Thermococcus kodakarensis, belonging to the same family (Thermococcaceae), which has been published more recently (in 2004 [ 21]).
As a result, this discrepancy is not strongly supported and warrants further investigation.
The discrepancy in ECM composition strongly affects cell behavior, so it is paramount to reproduce such differences in synthetic systems.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com