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The final research question is on the discrepancy of scores assigned by the two methods.
Although there are many reasons for discrepancy of scores between whole-section analysis and MMIHC such as inborn errors with IHC itself (intraobserver and interlaboratory variations), specimen selection, processing and representativeness of MMIHC result, total cases showing discordance in this study were 34 cases.
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Based on 300 writing samples graded by 14 raters, this research continues the comparison of the two scoring methods in two ways: examine rater reliability for each method and investigate the discrepancy of the scores assigned by them.
Third, and perhaps most notable, was the large discrepancy of the scoring of diminished physical function and global QOL on the QLQ-C30 among SCT patients who concurrently perceived no change or improvement in the corresponding SSQ items.
We did not find it statistically appropriate to include this in the calculation of discrepancy scores and kappa statistics.
We failed to find any systematic or consistent patterns and the correlation coefficients between the discrepancy scores of each type of alcoholic drink and the number of drinking days were all very low (max=0.33, for consumption of beer and drinking days for women).
The discrepancy score of Fibrotest was significantly higher than that of local or expert pathologists (p < 10-3).
When considering consensus reading by experts as reference, the discrepancy score of FibroMeter2G was significantly lower than that of local pathologists (p = 0.043) but significantly higher than that of the expert pathologist (p = 0.006, Table 3).
The ratio of the lower average divided by the higher average was then multiplied to each disagreeing phosphodiester bond score from the winning sequence, thereby proportionally penalizing the discrepancies and maintaining the principle of scores never being less than zero.
Among the remaining 111 patients, total agreement between preferred and actual participation in medical decision making (a discrepancy score of zero) was seen in 49 patients (44%), while 35% wanted a more active role (negative discrepancy scores) and 21% a more passive role (positive discrepancy scores) than they actually had.
However, there was no evidence for a group difference in ASA discrepancy taking into account the direction of scores (Mann–Whitney U test, P = 0.8).
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