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However, the discrepancy of effects between in vitro, animal, and human studies reflects the significance of herbal dosing in the modulation of CYPs [ 58].
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This discrepancy of effect of S100A6 expression in different carcinoma may be illustrated by the model proposed by van Dieck et al. that the binding of S100 proteins to p53 that can explain both activation and inhibition of p53-mediated transcription by alteration of the balance between monomeric p53 and tetrameric p53, depending on the concentration of p53 and the S100 proteins.
Similarly, discrepancies of effect-estimates (ORs and CIs) between high, medium or low family cohesion indicate moderation.
Therefore, the discrepancy of the effects in the two cell lines is probably connected to their ability to grow in normal cultural conditions and under 5-AZA treatment.
The discrepancy of DRZ effects on TOP2A in H9C2 cells in this and a previous work [ 15] may have been caused by our longer incubation times and by utilization of differentiated cells which express lower TOP2A levels.
This discrepancy of time-effect curves for the effect of GTN on headache and dilatation of MCA indicates that MCA is most likely not the primary source of pain in GTN-induced headache.
The reasons for the discrepancy of detected effect level are not clear, and the impacting factors may include cross-species, different exposure window during life course, different exposure route and/or duration to BPA for animal studies and different cell types or effect endpoints tested for cell experiments.
The discrepancy of the effect size on telomeres might be due to the small sample size of these other studies but also, in the second case, might point to the increased tendency for diabetes in South Asians compared to Caucasians [17].
The reasons for the discrepancy of the functional effects of ERK and PI3K are unclear.
The discrepancy of the therapeutic effects might be associated with their different metabolites, especially short-chain fatty acids [ 29].
However, because of the discrepancy of the time-effect curve for dilation of MCA and the effect on headache the dilation of the MCA is unlikely to cause NO-induced headache.
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