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The mixed findings suggest a discrepancy in severity of the disorder (moderate versus more severe forms of depression).
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This discrepancy in disease severity across the two studies is likely because the current study focused on all patients newly initiated with atypical antipsychotics regardless of line of therapy, resulting in a population with greater disease severity compared to the Jing et al population.
DOI: http://dx.doi.org/10.7554/eLife.09406.009 Another possible explanation for the discrepancy in disease severity between ttnan/n and ttnac/c mutants could be an internal promoter that produces a C-terminal isoform, which could partially rescue N-terminal truncations, especially in conjunction with expression of ttnb.
The discrepancy in phenotypic severities between hHtt and hAtx1 might come from a higher conservation of Atx1 and its interacting molecules in Drosophila.
While all these baz alleles display identical phenotypes during embryonic epithelial development, we observe strong discrepancies in the severity and penetrance of polarity defects in the follicular epithelium: polarity is mostly normal in baz EH747 and baz XR11 while baz and baz -8 show loss of polarity, severe multilayering and loss of epithelial integrity throughout the clones.
This discrepancy may be due to differences in severity of ligation (ligation of both L5 and L6 vs only L5) and/or timing of bupivacaine treatment (10 vs 30 min).
It seems logical that subjects with initial severe symptoms are prone to symptom progression, but there is a discrepancy in the evidence for radiographic OA severity and symptom severity [ 45].
The discrepancies are likely due to differences in severity or duration of ID in the cohorts examined.
Some authors treat subgastrocnemius bursitis as part of a popliteal cyst due to the presence of a communication between them, but our data imply that these two lesions should be treated as separate entities because of a discrepancy in their relation to increasing severity of effusion and synovitis.
If tangible support is more helpful for those with more severe symptoms the discrepancy in the two studies could reflect a difference in symptom severity in the two samples.
Similarly, discrepancies in HFMEA scores were found by Ashley and Armitage [ 19] who found differences in severity ratings determined by consensus between team members and those determined by averaging team members' individual scores.
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