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Still, the discrepancy in coverage reflects a certain hypocrisy.
This discrepancy in coverage counts could be attributed to a different treatment of quality scores in read counting and/or different default parameters among the callers, since we applied identical quality thresholds to the data.
Some of this discrepancy in coverage rates may have resulted from a selection bias from our convenience survey of individuals who already had access to health services due to their child's diagnosis.
A limitation of our study is that we did not assess if structural variation, such as common and rare copy number variants (CNVs), contribute to the discrepancy in coverage when analyzing a small subset of genes especially in the presence of population specific CNVs.
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A search of sequences from non-assembled bins did not detect the proposed missing sequence; likewise, no discrepancies in coverage could be found for the region proposed to contain the missing sequences.
Despite some discrepancies in coverage across samples, the high read coverage provided by the Miseq ensured sufficient coverage for each individual.
Such discrepancies in coverage are manifested in the entropy rate: the pseudo-human genome has entropy rate equal to the maximal value log2 4 or 2 bits per symbol and bounds from above the entropy rate of the human genome.
For example, there are discrepancies in coverage for home and community care depending on their recognition as a professionally-delivered service (e.g., delivered by a physician in a hospital versus delivered by a home care worker in the community) [ 23].
In spite of adjustment of the nationally reported vaccination coverage with survey data, a study by Lim et al. indicates that there is a remaining discrepancy in vaccination coverage between household surveys and the WHO and UNICEF estimations in low- and middle-income countries (7).
Such discrepancy in the coverage of Western media make the average Egyptian reflect on the reasons behind such double standards and clear bias.
In particular, recommendations on varicella vaccination were heterogeneous and led to a marked discrepancy in vaccination coverage observed through the country.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com