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Low growth rate was observed in the majority of the newborns from infected mothers (Figure 2A) resulting in obvious body size discrepancy (Figure 2B).
For TTP values censored at 14 months, 48% of the data had no discrepancy while all data where within two months discrepancy (figure 2).
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Not all nonalignments are discrepancies; Figure 4 illustrates such an example.
There also seems to some discrepancy between Figure 3D and the table in Figure 3 (e.g. figure 3D should show Baseline "A2" and Readaptation A2, not A1).
The following points should be addressed: Please comment on the apparent discrepancy between Figure 1 (and related) depletion of STIL that results in more PLK4 at centrioles compared to Figure 3 where STIL-cc that is not at centrioles at all does not show more, but less PLK4 at centrioles.
Finally, we have commented on the apparent discrepancy in Figure 1, which results from the fact that, even after puromycin selection, not all of the cells (we estimate 30%) that survive the short treatment with puromycin are transfected.
Please comment on the apparent discrepancy between Figure 4 and Ohta et al., 2014 who claim that PLK4 PB1 and 2, but not PB3, are required for STIL binding; Kratz et al., 2015 also show that PLK4 Polo Boxes are not sufficient for STIL binding.
10.7554/eLife.07888.023 Author response image 1. DOI: http://dx.doi.org/10.7554/eLife.07888.023 Please comment on the apparent discrepancy between Figure 4 and Ohta et al., 2014 who claim that PLK4 PB1 and 2, but not PB3, are required for STIL binding; Kratz et al., 2015 also show that PLK4 Polo Boxes are not sufficient for STIL binding.
These are: whether virus effects could be due to avidity, clarifying the meaning of tau in Table 2, expanding on the rationale for subsampling in the Punctuated evolution section, the apparent discrepancy between Figure 4 and its legend, eliminating the orphan paragraph described in point #3 below, and a paragraph in the Discussion summarizing the main biological results.
Explaining the discrepancy in figures, he blamed his min istry for "not being well-prepared for public health emergencies" and admitted that "the epidemic control system is comparatively weak".
(The discrepancy in figures could mean that the Acushnet reported to the Joseph Maxwell the total she had taken since leaving home on 3 January 1841, not just the amount she then had on board).
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