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In a study examining transition of scientific meeting abstracts to full-length journal article, 41% of publications exhibited significant discrepancies when compared to the original abstract data [16].
This study was also motivated by the observation that data obtained from rats, the most commonly utilized model in preclinical drug discovery pharmacokinetics studies, exhibit numerous examples of discrepancies when compared to data obtained from humans [ 4, 21].
We performed next generation sequencing using Illumina MiSeq technology on the DSM10061 strain of Clostridium autoethanogenum and observed 243 single nucleotide discrepancies when compared to the published finished sequence (NCBI: GCA_000484505.1), with 59.1 % present in coding regions.
Review revealed that these data elements were being poorly collected in quantity (<1% of cases with a valid response) and quality (75% cases with discrepancies when compared to clinical staging or PSA recurrence data).
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The results show that the analytical design method is conservative, with little discrepancy when compared to the numerical model.
However, the simulated wet-bulb temperature in the hot burnt gas between the two reaction zones in addition to the profile along the spray centreline show a large discrepancy when compared to measurements.
These results too were lower than national averages, but represented a large discrepancy when compared to Princeton's self-reported Clery numbers.
If we restrict our attention to parameter sets yielding the least discrepancy when compared to the cross-sectional community prevalence data from the PRET study in Niger, what is the best time to treat?
Immunostaining against GABA have shown discrepancy when compared to in-situ hybridization against glutamate decarboxylase, indicating that some cells may express very low levels of GABA leaving this as an insufficient choice for immunostaining.
The household rapid urease test showed a very low positive predictive value for H. pylori associated gastric diseases and a high discrepancy when compared to histology; consequently these data were excluded from the study (data not shown).
Many dating charts are now in use though developed from different populations resulting in discrepancies when compared or applied to a specified population hence there is a need for an international reference dating equation and chart [ 11- 15].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com