This represents a potential obstacle to successful biomarker discovery, validation, and application (Dibben et al., 2012; Gerlinger et al., 2012).
Rational and efficient development of new molecular cancer therapeutics requires discovery, validation, and implementation of informative biomarkers.
Once defined, the team then attempted to bring a scientific approach to understanding the lifecycle of those startups — almost like a behavioral psychologist — by defining six stages of development they evolve through: Discovery, Validation, Efficiency, Scale, Sustain, and Conservation.
Thus, translational medicine is not pretending to discover new goals and values but its essence resides more in emphasizing the need to enhance the efficiency of discovery validation recognizing the increasing obstacles.
There is an ever-increasing demand for the discovery, validation, and application of clinically useful molecular biomarkers that enable patient stratification, diagnosis, monitoring of disease progression, or a better understanding of drug response (safety and efficacy) [1]-[3].
This opens up new avenues for large-scale discovery, validation, and clinical applications of mRNA biomarkers in human diseases.
As ELM represents the most comprehensive resource of validated SLiM occurrences available, it is still the best benchmarking dataset for SLiM discovery validation.
He presented multiple reasons for the significant gap between biomarker discovery, validation and translation.
Increased investments are necessary to support biomarker discovery, validation, and translation into clinical tools.
In addition, we will discuss several emerging technologies, which have potentials in novel biomarker discovery validation and diagnostics in psoriasis.
VKT, SW, SKS and EA contributed to DNA sequencing, sequence analysis, SNP discovery, validation and introgression mapping experiments.
