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As microRNA-based research evolves from discovery to validation, robust, multiplex methods that can be performed easily at the bench are necessary to continue advancements in the field.
Targeting teams in Central and Eastern Europe (although, interestingly, the accelerator will accept applications from anywhere), Eleven is offering startups €50,000 in funding for 10-15% of equity with a remit to help them go from discovery to validation, taking them past an initial MVP to be seed and series A investment ready.
The long path from biomarker discovery to validation and clinical use has resulted in exhaustive lists of biomarker candidates but relatively few are currently used in patient management.
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Even with the abundance of technical challenges and innovations that will surround mass spectrometry in the decades to come, the omnipresent burden of false discovery will always need recognition when transitioning from biomarker discovery to biomarker validation.
Thus, within the framework of an initiative such as SCAN-B, the cycle time from biomarker discovery, to independent validation, to clinical implementation can be made more rapid and efficient.
We have developed a comprehensive biomarker pathway that extends from discovery through to validation on a TMA platform.
We have developed a comprehensive biomarker development pathway, extending from discovery through to validation on TMAs, that can yield novel multi-protein panel signatures for use as a prognostic determinant in breast cancer.
"To the best of my knowledge, no previous genome-wide epigenetics study has taken such efforts from initial discovery to replication to experimental validation," adds Lutz Breitling, an epidemiologist who worked on epigenetics at the German Cancer Research Center in Heidelberg, Germany.
While SNPs typically provide more useful markers in many basic and applied research areas, such as population genetics, gene discovery, plant breeding and germplasm identification [ 10- 12], the steps from sequencing and SNP discovery to SNP marker design and validation are generally lengthy and expensive.
Organizations use PathwayStudio to support target discovery and validation, to better understand the underlying mechanisms of disease in the context of literature-based and experimental evidence.
The SCAN-B Initiative should significantly reduce the time to discovery, validation, and clinical implementation of novel molecular diagnostic and predictive tests.
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