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Lucky Strikes, Eastman's ciagarette, are placed on the leather-topped "Discovery" table he commissioned with a tableau of Columbus's ships sailing for the New World.
Multiple testing adjustments were not performed because the study is in essence replication of previous studies regarding individual SNPs (not discovery) (Table 5).
In addition to the existing InterMine classes, we have customised the InterMine data model and created new classes to collate biological data types most likely to help facilitate target discovery (Table S1).
Different NGS platforms and DNA sources can be used for SNP discovery (Table 6).
Overall, 14 498 726 sequences were screened for SSR discovery (Table 2).
Women who delayed help-seeking in both countries shared similar barriers to help-seeking after symptom discovery (table 4).
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Given the FDR q-values of the SNPs in the discovery set (Table 2 and Table 3), it seems that some SNPs with true associations were not confirmed.
Statistical significance was set at p < 0.05 for all tests and corrected for multiple comparisons [ 32] of 890 protein spots of the discovery phase (Table OR2) and across both study phases (Table 2).
This approach provided no improvement in DEG discovery (Supplementary Table 1), as inter-sample variations remained problematic, as shown in Fig. 2. Adding to these obstacles were issues of reproducibility, as, we found no common DEG among the three cohorts.
This analysis resulted two and one DEGs identified before and after the sample quality weighting procedure, with no better performance obtained by the additional four methods for DEG discovery (Supplementary Table 4).
In the final model fitted to the discovery dataset (Table 1), all SNPs in the model were coded as quantitative variables (trend test) rather than factors.
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