We've had a week and a half of non-stop doctors' appointments, batteries of tests, children saying contentedly, "Hmh, another takeaway", all culminating in the discovery that size isn't everything, after all.
A discovery of "size effect" stimulated the development of several new powder consolidation techniques, specifically designed for manufacturing dense nanostructured materials [3 7].
Parameter settings are comprised of the product of subset and iteration numbers (SI, range 40 160) and 3DGF (range 1.0 4.0 pixel (Infinia and Discovery; pixel size, 4.4 mm) or 5 17 mm (Brightview and Symbia)).
We fully acknowledge that our discovery sample size is small (though matched and enriched for clinical outcomes) and we may have missed significant positive findings because of this.
This is a possible explanation for the relatively small amount of phenotype variance explained by polygenic scores in the current study, estimates of explained variance in this form of analysis being strongly affected by discovery sample size.
Discovery sample size is usually small due to the necessity to prospectively collect tissue for analysis, and treatment sensitivity is not distributed equally among various phenotypic subtypes of breast cancer.
This could be due to the small discovery cohort size, the inherent noise in different microarray experiments leading to confounded results [ 36], and/or, the impact of the clinicopathological characteristics of samples selected for a particular study on candidate gene selection.
Large discovery sample sizes and well-defined environmental variables in the target samples will increase precision and prediction accuracy in the risk-profiling framework.
As a result of the relatively small ADHD GWAS discovery sample sizes, power to detect susceptibility variants is low, and aggregate scores based on GWAS are likely to be based on a poor signal-to-noise ratio (4,34).
