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The academic hit discovery sector, together with industry, can have an active role in these ambitions.
The result is a growing clinical crisis and an increasingly disengaged drug discovery sector (Cooper & Shlaes, 2011).
Yet despite their success, the drug discovery sector has turned away from these molecules over the past two decades in favor of small synthetic molecules.
It is also strategically important to ensure that as the academic drug discovery sector develops, it remains operationally and culturally distinctive from the pharmaceutical sector so that they can work in synergy rather than in competition.
While the pharmaceutical sector has to moderate its strategy to cope with challenging business and economic times, the academic drug discovery sector has the potential to develop to a level of maturity and robustness with which it can contribute meaningfully to the development of new mode-of-action therapies against a range of diseases, not least neglected and niche diseases.
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The key idea behind the COND mechanism is that each directional node performs neighbor discovery in each sector using a contention-based polling mechanism.
The drug discovery and development sector of National Cancer Institute (NCI), the Developmental Therapeutics Program (DTP), has utilized a panel of 60 human tumor-derived cell lines to screen the chemotherapeutic potential of more than 75000 compounds [5], [6].
Hit discovery in this sector should have the confidence and freedom to tackle pathway-based assays that provide a repertoire of potential targets and intervention points for chemical matter.
Their final report, which can be accessed at the NCI web site at, provides concise recommendations for improving discovery in all sectors: clinical, epidemiologic, and basic.
Among them, tech investor Chris Morton launched Lyst four years ago, applying the Spotify model of music discovery to the fashion sector.
Most important, the Treasury hopes that the program will encourage private sector price discovery.
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