However, because of the very nature of a pervasive regionally occurring, but spatially variable resource density and reservoir characteristics, the development of shale gas is characterized by lower geologic discovery risk, but higher commercial production risk (Gray et al. 2007).
This journey to preserving rawness and authenticity is not one of perfection, but rather one of discovery, risk, trial, mistakes, awareness and at times little or big personal victories.
Although the photo cannot be published here for copyright reasons, its untimely discovery risks Mr Cameron facing a re-run of the embarrassment he suffered over the 1987 picture.
Remond says strong faith is built on intellectual, emotional and psychological rigour, and that to "seek God in our world, lives and in all things – that is a journey of great discovery, great risk, great struggle, and times of great doubt are part of that journey.
Even though the app store gold rush as not yet subsided, Apple will eventually have to address some of the challenges facing its third-party developers in the future by offering better tools for app discovery, or risk having them turn their attention to other platforms where visibility and findability is better.
25 The discovery that risk of pancreatic cancer progressively increases with worsening hyperglycaemia has important implications.
Hence, discovery of risk factors for the recurrence and metastasis will be of great significance in the prognosis and management of NPC patients.
Since the human genome became available a decade ago, genome-wide association study gradually became the predominant method for the discovery of risk genes/variations, as compared to the traditional target gene/loci approach.
The development and implementation of powerful bioinformatics and biostatistics has been arguably a main driver of recent biobanking successes not only in the discovery of risk factors for common diseases but also in developing 'systems medicine': connecting multiple levels of -omics data and thereby enabling discovery of new biological pathways, disease mechanisms and medications.
Since the discovery of risk variants in PPARG in 1998, KCNJ11 in 2003, and TCF7L2 in 2006, the emergence of GWAS in 2007 combined with access to large well-powered study populations has quickly expanded the list of validated type 2 diabetes susceptibility alleles [ 14].
As such, a major impediment to progress in the discovery of risk loci for hearing in humans is the lack of control of the many environmental factors that affect hearing during the lifetime, and, to date, only a limited number of large-scale GWAS for hearing phenotypes have been undertaken in humans.
